ZURICH — Roche could complete studies of its medicine Actemra in COVID-19 patients as early as this month, the head of the Swiss drugmaker’s US-based Genentech unit told a Swiss newspaper, as it seeks to repurpose the rheumatoid arthritis drug.
“We’re testing all over the world and we’ve reached half of the planned 330 patients, perhaps it will be more,” said Alexander Hardy, Genentech’s head, in the interview with the Neue Zuercher Zeitung published on Wednesday.
“We’ll be finished in May or June. Parallel to that, we have 15 control studies worldwide. There are many questions: Does Actemra help reduce the need for ventilators? When should Actemra be administered? And which patient groups?”
Hardy acknowledged success would not solve the pandemic, but said it could help reduce mortality and health problems and take the heat off intensive care units where ventilators in some regions are in high demand and where many COVID-19 patients who eventually need breathing assistance die.
Should the anti-inflammation drug Actemra – beyond arthritis, it is also used for cancer patients to counteract massive, life-threatening immune system reactions called cytokine storms – turn out to help, Hardy said Roche has boosted its production from several hundred thousand doses to more than a million.
“We’re taking a big risk and expect that the studies will be positive,” Hardy told the newspaper. “If that’s not the case, then we’re going to have a surplus.”
In the former case, he sees demand for Actemra for COVID-19 peaking over the next 12-18 months until a vaccine is available.
Top US general: ‘We don’t know’ if coronavirus emerged from Chinese lab
WASHINGTON — The top US general said on Tuesday it was still unknown whether the coronavirus emerged from a wet market in China, a laboratory or some other location, but reaffirmed the US view that it was probably not man-made.
“Did it come out of the virology lab in Wuhan? Did it occur in a wet market there in Wuhan? Did it occur somewhere else? And the answer to that is: We don’t know,” Army General Mark Milley, chairman of the Joint Chiefs of Staff, told a news conference, adding the US government was looking into it.
The remarks stood in contrast to Secretary of State Mike Pompeo’s assessment on Sunday that there was “a significant amount of evidence” that the new coronavirus emerged from a Chinese laboratory.
